biotechnological reduction of tobacco (nicotiana tabacum l.) toxicity

Authors

سمانه ستار

samane sattar department of pharmacognosy, faculty of pharmacy, isfahan university of medical sciences, isfahan, iran. غلامرضا اصغری

gholamreza asghari isfahan pharmaceutical sciences research center, isfahan university of medical sciences, isfahan, iran. علی اکبر احسان پور

ali akbar ehsanpour department of biology, faculty of science, university of isfahan, isfahan, iran.

abstract

background: nicotiana tobacco contains large amounts of alkaloid nicotine. tobacco plant is used for smoking and causes many health problems since it is high in nicotine which is one of the widely-recognized toxic compounds with serious side effects for different body organs. reducing nicotine content of this plant is a way to reduce its health hazards in cigarette smokers. utilizing the new methods of genetic engineering can modify nicotine levels in the plant. in this study, through transferring the blocking gene, the pathway of nicotine biosynthesis was blocked to produce transgenic tobacco with low levels of nicotine. methods: transgenic plants carrying t dna, and non-transgenic plants were grown on ms medium. then their leaves were dried and powdered. the plants were extracted with alkali solution. eventually, the nicotine content of the extract were analyzed using gc. results: the analysis of extracts showed a reduction in the nicotine content of the transgenic plant (contain t-dna) in comparison with non-transgenic plants. conclusion: tobacco with lower nicotine reduction can reduce the toxic effects of smoking on smokers and can facilitate withdrawal from it.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Biotechnological Reduction of Tobacco (Nicotiana Tabacum L.) Toxicity

BACKGROUND: Nicotiana tobacco contains large amounts of alkaloid nicotine. Tobacco plant is used for smoking and causes many health problems since it is high in nicotine which is one of the widely-recognized toxic compounds with serious side effects for different body organs. Reducing nicotine content of this plant is a way to reduce its health hazards in cigarette smokers. Utilizing the new ...

full text

Coproporphyrinogenase in tobacco (Nicotiana tabacum L.).

1. Coproporphyrinogenase was extracted and purified from tobacco (Nicotiana tabacum L.). Enzyme activity was mainly located in mitochondria rather than in chloroplasts. The enzyme was purified by differential centrifugation, ammonium sulphate fractionation, calcium phosphate gel adsorption and dialysis. A 69-fold final purification was obtained. 2. An apparent K(m) value of 3.6x10(-5)m was foun...

full text

Monograph of Tobacco (nicotiana Tabacum)

The use of tobacco dates back to the ancient civilizations of the Americas, where it played a central role in religious occasions. The peoples smoked tobacco in cigars and pipes and chewed it with lime, for its pleasurable euphoriant effects. In the 16 th century, Europeans spread the use of tobacco in North America, while the Spanish bring it into Europe. In the 1559, Jean Nicot, the French am...

full text

High-Efficiency Agrobacterium-Mediated Transformation of Tobacco (Nicotiana tabacum)

To improve Agrobacterium-mediated transformation of tobacco, factors influencing gene delivery, including genotype of the plant, bacterial strain, and Agrobacterium transformation procedure, were tested via direct somatic embryogenesis. Leaf tissue of three different tobacco genotypes (Nicotiana tabacum L. cvs. Samsun, and Xanthi, and N. benthamiana) we...

full text

Genetic Study of Agronomic Traits in Tobacco (Nicotiana tabacum L.) Using Hayman’s Graphical Analysis of Diallel

For the purpose of graphical analysis and estimation of genetic parameters related to yield and its components, six tobacco genotypes was crossed in half -diallel mating design. In this study, the F2 progenies and their parents were evaluated in a randomized complete block design with three replications. The results of analysis of variance indicated a significant difference between genotypes fo...

full text

My Resources

Save resource for easier access later


Journal title:
iranian journal of toxicology

جلد ۶، شماره ۱۸، صفحات ۶۹۹-۷۰۳

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023